Stem cell therapy for autism in Mumbai

NeuroGen Brain & Spine Institute commenced on 17th December 2008. From treating around 150 patients in the initial year we have steadily reached a point to where we treat approximately 250 patients in a month. We have not only expanded from a small facility to an 11 storey building, in a beautiful, homely, locality, but also grown in terms of manpower and resources. We began as a team of 6 professionals in the year 2008 but have now expanded to a larger family consisting of almost 200 inhouse and outsourced employees. The entire set up of the hospital has been designed to be patient centric.

Some time ago donated organs were transplanted to replace the diseased or failed organs in the recipients. Soon the number of recipients exceeded the number of donated. To overcome this demand, cell therapy offered the possibility of replacement of the damaged cells of tissue with new cells. Stem cell infusion helps to treat a plethora of conditions including cerebral palsy, spinal cord injury, intellectual disability, and other neurodegenerative syndromes as well.

Stem cells have the potential to develop into different cells of the tissues (of the body) and the ability of self-renewal. When serving as a repair system, the stem cells divide without limit as long as the person is alive. As they divide, they remain as stem cells or develop into cells with more specialized functions, like a brain cell or a muscle cell.

Stem cells, from different sources, have three common properties: The stem cells do not have tissue-specific structures to perform specialized functions.

Impairments linked to neuromuscular conditions are usually irreversible due to inadequate cell regeneration or impaired cells in the central nervous system. It was observed that the cellular characteristics of autologous stem cells had the capability of treating major neurological disorders without incurring any side effects. With their neurotrophic properties, self-renewal & differentiation capacity, and immune modulation effects, the bone marrow-derived stem cells are considered as a promising candidate for treating disorders related to the nervous system.

For cell treatment, bone marrow derived mesenchymal stem cells are isolated from the marrow tissue (extracted from the patient’s hip bone) in an expedited, painless and safe way. By centrifugation procedure, a sufficient number of stem cells are separated from the unwanted tissue within a few hours. These injectable stem cells are infused intrathecally into the spinal area or the damaged muscle points, as per the need of the patients.

These bone marrow-derived stem cells have many useful properties that lead to great clinical improvement in post-cell-based therapy. According to various clinical trials, treatment with bone marrow derived mesenchymal stem cells have shown improvement in patients with traumatic brain injury, spinal cord injury and other neurological disorders through axonal sprouting and remyelination, potential to replace/protect the damaged neurons/cells, and neovascularization.

How do the infused stem cells act? Once infused into the body,

– The infused stem cells journey toward the nervous system and blend into the neural circuits to mend or improve the disrupted synaptic transmission.
– Post infusion, improved neuropathological condition, upregulated Aß clearance and reduced deposition is detected within a short period.
– The infused stem cells reduce neuroinflammation and provide protective immunomodulatory effect.
– The stem cells secrete neurotrophic influence and nerve growth factors, bringing cognitive and memory improvement in patients.

Apart from encouraging effects, renewed brain plasticity is also observed in patients following intrathecal delivery of stem cells. With the new medical breakthrough in stem cell therapy, the treatment has become a highly sought-after curative. To know about the treatment efficacy, one must understand the efficiency of stem cells in terms of engraftment, migration, cytokines and growth factors. However, cell-based therapy is a promising contribution to regenerative medicine and has gained considerable clinical attention. Read extra info at https://www.neurogenbsi.com.

Considerations Before Starting Treatment: The needs of a child with cerebral palsy aren’t solely based on correcting their physical disabilities. There are also social and emotional aspects of living a more fulfilling life. These aspects shouldn’t be ignored when considering treatment and therapy. Many children are content with their disabilities. As a parent, it’s important to consider their feelings. Some treatments can be stressful and uncomfortable, and may not be in the best interest of the child. It’s important to discuss the physical and emotional impacts of all treatments with specialists and most importantly, the child.

A few advices to help your child with autism: Be consistent. Children with ASD have a hard time applying what they’ve learned in one setting (such as the therapist’s office or school) to others, including the home. For example, your child may use sign language at school to communicate, but never think to do so at home. Creating consistency in your child’s environment is the best way to reinforce learning. Find out what your child’s therapists are doing and continue their techniques at home. Explore the possibility of having therapy take place in more than one place in order to encourage your child to transfer what he or she has learned from one environment to another. It’s also important to be consistent in the way you interact with your child and deal with challenging behaviors. Look for nonverbal cues. If you are observant and aware, you can learn to pick up on the nonverbal cues that children with ASD use to communicate. Pay attention to the kinds of sounds they make, their facial expressions, and the gestures they use when they’re tired, hungry, or want something.

Look for the best! Don’t define your child according to his problem – they grow up going through a cascade of problems, challenges that you can tackle together, carefully and deliberately. Do not make a goal of “normality”. People with autism can have extraordinary creativity and intuition, and your goal should be to encourage your child to enjoy his or her strengths and to strengthen the vulnerable. Awareness of what you can control and what you cannot control: The set of genes we are born with is the one we will have all our lives, but it does not mean that our future is precise. The power of genes is shaped by the environment in which we live. Therefore, your goal should be to create a supportive environment – for you and your child.

US researchers are now trying to find a way to use stem cells for patients with paralysis or brain injury, for patients with type 1 diabetes, those with spinal cord injury, heart disease, people who have a heart attack or disorder neurological disorders such as multiple sclerosis. Many of the studies have been carried out on animals, and the results are in an early stage. It is important to note that the treatment with stem cells is not done with the patient’s own stem cells, because this is how the premises of the disease return are created. However, there were exceptions, proof stands a case from 2007, published in the journal Pediatric, of a child who was ill with leukemia and who was transplanted his own stem cells harvested at birth, following that 5 years after the intervention, the child to be completely healthy. Instead, it is indicated that the stem cell donors are the patient’s brother or sister. But in only 25% of cases it is shown that the brother is compatible with the patient, and 7 out of 10 patients must seek a donor outside the family.

Dr Alok Sharma is a renowned and respected Neurosurgeon, Neuroscientist and Professor across the world in medicine with an extensive surgical expertise & experience in the areas of Neurosurgery, Neuroscience and Stem cells. In 1995, Dr Alok Sharma held a place at the Karolinska hospital in Stockholm Sweden where neural transplantation was done for the first time ever in the world. In 1998, Dr Alok Sharma was placed at the University of Colorado health sciences center in Denver, USA where the world’s first randomized trial for cell transplantation was done for Parkinson’s disease. Dr Alok Sharma obtained his MBBS, M.S. and M.Ch. from the Seth G.S. Medical College & KEM Hospital of Mumbai University. Subsequently, Dr Alok Sharma did fellowships in two departments that were first to do neural transplantation. Read extra details Dr Alok Sharma.